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- Title
Bone marrow steady-state CD34+/CD7- cell content is a predictive value of rG-CSF-mobilized CD34+ cells.
- Authors
Osma, M.M.; Ortuno, F.; de Arriba, F.; Lozano, M.L.; Heras, I.; Moraleda, J.M.; Vicente, V.
- Abstract
Thirty-four patients diagnosed with breast cancer were included in a prospective study evaluating the bone marrow (BM) CD34[sup+]/CD71[sup-] cell content, as a predictive parameter of the CD34[sup+] cell mobilization after rGCSF administration. Analysis of the concentration of medullary CD34[sup+]/CD71[sup-] cells before priming schedules was significantly related with the collection of CD34[sup+] cells in apheresis day 1 (P = 0.03, r = 0.36), apheresis day 1 + day 2 (P = 0.01, r = 0.42) or the total CD34[sup+] cells collected (P = 0.005, r = 0.47). A BM CD34[sup+]/CD71[sup-] cell concentration greater than or less than a cut-off value of 30/μl was significantly associated with the yield of CD34[sup+] cells collected by cytapheresis procedures (mean values 3.12 x 10[sup6]/kg, and 2.19 x 10[sup6]/kg, respectively, P = 0.013). These results suggest that in breast cancer patients undergoing priming with rG-CSF, steady-state BM CD34[sup+]/CD71[sup-] measurement is a relevant predictive parameter of CD34[sup+] mobilization.
- Subjects
BONE marrow; GRANULOCYTE-colony stimulating factor; CD antigens; AUTOTRANSPLANTATION; LEUKAPHERESIS
- Publication
Bone Marrow Transplantation, 1998, Vol 21, Issue 10, p983
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1701227