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- Title
Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study.
- Authors
Ong, Yi Ying; Tint, Mya-Thway; Aris, Izzuddin M; Yuan, Wen Lun; Chen, Ling-Wei; Fortier, Marielle V; Choo, Jonathan; Ling, Lieng Hsi; Shek, Lynette; Tan, Kok Hian; Gluckman, Peter D; Yap, Fabian; Chong, Yap-Seng; Godfrey, Keith M; Chong, Mary F-F; Chan, Shiao-Yng; Eriksson, Johan G; Wlodek, Mary E; Rolfe, Emanuella De Lucia; Ong, Ken K
- Abstract
Background Early epidemiological studies have associated low birthweight with increased cardiovascular risk. We aimed to examine whether the fat and fat-free components of birthweight have differing relationships with childhood cardiovascular risk markers. Methods In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, air displacement plethysmography was conducted within 24 h after delivery in 290 naturally conceived singletons. We investigated associations of newborn cohort-specific standardized z-score of fat mass, fat-free mass, body fat percentage and birthweight on child (at 6 years of age) carotid intima-media thickness, pulse wave velocity, blood pressure, prehypertension/hypertension (>110/70 mmHg) and standardized systolic and diastolic blood pressure (SBP and DBP) trajectories (at 3–6 years of age), taking account of maternal education, height, tobacco exposure, parity, ethnicity, child's sex, gestational age, age at follow-up, and other maternal factors. Results Clear inverse associations were seen for blood pressure with z-score of fat mass [SBP, β (95% CI): −1.31 mmHg (−2.57, −0.06); DBP: −0.79 mmHg (−1.74, 0.15)] and body fat percentage [SBP: −1.46 mmHg (−2.73, −0.19); DBP: −0.80 mmHg (−1.75, 0.16)], but not with fat-free mass [SBP: 0.27 mmHg (−1.29, 1.83)]; DBP: −0.14 mmHg (−1.30, 1.03)]. Being in the lowest tertile of fat mass or body fat percentage was associated with higher blood pressure trajectories and prehypertension/hypertension risk [OR (95% CI), fat mass: 4.23 (1.41, 12.68); body fat percentage: 3.22 (1.09, 9.53)] without concomitantly higher overweight/obesity risk. Conclusions At birth, low adiposity was associated with increased childhood blood pressure. Low newborn adiposity might serve as a marker of poor fetal growth or suboptimal intrauterine conditions associated with hypertension risk later in life.
- Subjects
SINGAPORE; BODY composition; DIASTOLIC blood pressure; CARDIOVASCULAR diseases risk factors; ADIPOSE tissues; SYSTOLIC blood pressure; CAROTID intima-media thickness; BLOOD pressure
- Publication
International Journal of Epidemiology, 2022, Vol 51, Issue 6, p1835
- ISSN
0300-5771
- Publication type
Article
- DOI
10.1093/ije/dyac154