We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Maternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort study.
- Authors
Yeyi Zhu; Olsen, Sjurdur F.; Mendola, Pauline; Halldorsson, Thorhallur I.; Rawal, Shristi; Hinkle, Stefanie N.; Yeung, Edwina H.; Chavarro, Jorge E.; Grunnet, Louise G.; Granström, Charlotta; Bjerregaard, Anne A.; Hu, Frank B.; Zhang, Cuilin; Zhu, Yeyi
- Abstract
<bold>Background: </bold>Artificial sweeteners are widely replacing caloric sweeteners. Data on long-term impact of artificially sweetened beverage (ASB) consumption during pregnancy on offspring obesity risk are lacking. We prospectively investigated intake of ASBs and sugar-sweetened beverages (SSBs) during pregnancy in relation to offspring growth through age 7 years among high-risk children born to women with gestational diabetes.<bold>Methods: </bold>In a prospective study of 918 mother-singleton child dyads from the Danish National Birth Cohort, maternal dietary intake was assessed by a food frequency questionnaire during pregnancy. Offspring body mass index z-scores (BMIZ) and overweight/obesity status were derived using weight and length/height at birth, 5 and 12 months and 7 years. Linear regression and Poisson regression with robust standard errors were used, adjusting for major risk factors.<bold>Results: </bold>Approximately half of women reported consuming ASBs during pregnancy and 9% consumed daily. Compared to never consumption, daily ASB intake during pregnancy was positively associated with offspring large-for-gestational age [adjusted relative risk (aRR) 1.57; 95% CI: 1.05, 2.35 at birth], BMIZ (adjusted β 0.59; 95% CI: 0.23, 0.96) and overweight/obesity (aRR 1.93; 95% CI; 1.24, 3.01) at 7 years. Per-serving-per-day substitution of ASBs with water during pregnancy was related to a lower overweight/obesity risk at 7 years (aRR 0.83; 95% CI: 0.76, 0.91), whereas SSB substitution with ASBs was not related to a lower risk (aRR 1.14; 95% CI: 1.00, 1.31).<bold>Conclusions: </bold>Our findings illustrated positive associations between intrauterine exposure to ASBs and birth size and risk of overweight/obesity at 7 years. Data with longer follow-up are warranted.
- Subjects
DENMARK; SOFT drinks; SOFT drinks &; health; GESTATIONAL diabetes; OBESITY; PREGNANCY complications; BEVERAGES; BODY weight; LONGITUDINAL method; MULTIVARIATE analysis; NUTRITIONAL requirements; CHILDHOOD obesity; PREGNANT women; REGRESSION analysis; SWEETENERS; BODY mass index; DIETARY sucrose
- Publication
International Journal of Epidemiology, 2017, Vol 46, Issue 5, p1499
- ISSN
0300-5771
- Publication type
journal article
- DOI
10.1093/ije/dyx095