We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quinazoline‐Assisted ortho‐Halogenation with N‐Halosuccinimides through Pd(II)‐Catalyzed C(sp<sup>2</sup>)−H Activation.
- Authors
Wang, Yong; Wang, Hui; Yang, Qifan; Xie, Shihua; Zhu, Hongjun
- Abstract
An efficient quinazoline‐assisted ortho‐halogenation of 2‐arylquinazolines has been developed using N‐halosuccinimides as halogen sources with Pd(II)‐catalyzed C−H bond activation. No additional ligand and oxidant are required. This protocol is highly regioselective and applicable to a broad range of quinazoline substrates bearing different functional groups, giving yields of up to 98 %. The mechanism of the quinazoline ortho‐halogenation was investigated by comprehensive experimentation.
- Subjects
QUINAZOLINE; FUNCTIONAL groups; SCISSION (Chemistry)
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 33, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202200316