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- Title
Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
- Authors
Crawford, Stephen O; Hoogeveen, Ron C; Brancati, Frederick L; Astor, Brad C; Ballantyne, Christie M; Schmidt, Maria Inês; Young, Jeffery Hunter
- Abstract
<bold>Background: </bold>Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.<bold>Methods: </bold>To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.<bold>Results: </bold>The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults.<bold>Conclusions: </bold>Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
- Subjects
BLOOD lactate; TYPE 2 diabetes; ATHEROSCLEROSIS risk factors; MAGNETIC resonance imaging; LACTIC acid; EPIDEMIOLOGY; PHOSPHORYLATION; GLYCOLYSIS
- Publication
International Journal of Epidemiology, 2010, Vol 39, Issue 6, p1647
- ISSN
0300-5771
- Publication type
journal article
- DOI
10.1093/ije/dyq126