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- Title
Comparative Solubility Prediction in Four Binary Solvent Using Extended Hildebrand Solubility Approach (EHSA).
- Authors
Dubey, Raghvendra; Dubey, Kushagra
- Abstract
Solubility of etodolac was predicted and compare in four binary solvent systems (ethanol, methanol, dioxane and PEG with water) in term of solute solvent interaction using extended Hildebrand solubility approach (EHSA). In EHSA the solubility equation employs the term interaction energy (W) to replace the geometric mean (δ1δ2), where δ1 and δ2 are the cohesive energy densities for the solvent and solute, respectively. The energy term obtained for all binary systems were regressed against a polynomial in δ1. The ideal solubility of Etodolac was calculated by heat of fusion and absolute melting point was obtained from DSC data reported in literature. Using floatation & experimentally solubility method, the Molar volume and solubility parameter of Etodolac were calculated from Fedor fragmental constant. Tiscon Sonicator A-72 & UV-Visibile spectrophotometer shimadzu UV-1700 were used in experimental evaluation of solubility of Etodolac. The result indicate that the solubility of Etodolac in all binary solvents appear as a bell-shaped profile with a solubility maximum below the ideal solubility of the drug. This is an attribute to solvation of the drug with the binary mixtures and indicates that the solute-solvent interaction energy is larger than the geometric mean (δ1δ2) of regular solution. It was observed that in all binary systems (20- 40%) maximum solubility occurs between 11.24δ to 14.80 δ.
- Subjects
DRUG solubility; ETODOLAC; SOLVENTS; FLOTATION; BINARY number system
- Publication
International Journal of Pharmacy & Life Sciences, 2018, Vol 9, Issue 2, p18
- ISSN
0976-7126
- Publication type
Article