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- Title
Mutual effect of cerebral amyloid β and peripheral lymphocytes in cognitively normal older individuals.
- Authors
Yasuno, Fumihiko; Kazui, Hiroaki; Kajimoto, Katsufumi; Ihara, Masafumi; Morita, Naomi; Taguchi, Akihiko; Yamamoto, Akihide; Matsuoka, Kiwamu; Takahashi, Masato; Nakagawara, Jyoji; Tsuji, Masahito; Iida, Hidehiro; Kishimoto, Toshifumi; Nagatsuka, Kazuyuki
- Abstract
<bold>Objective: </bold>We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the cortical amyloid burden or vice versa in cognitively normal older subjects.<bold>Methods: </bold>We applied [11 C] Pittsburgh compound B (PiB)-positron emission tomography to 36 cognitively normal older individuals, and Aβ deposition was quantified by cortical binding potential (PiB-BPND ). Blood samples were obtained, and lymphocyte subsets were evaluated. We examined differences between low and high PiB-BPND groups in the percentage of B cells, T cells, helper T cells, cytotoxic T cells, regulatory T cells, and natural killer cells. RESULTS: Subjects with high PiB-BPND showed significantly higher percentage of cytotoxic T cells (%CD3+ ). Correlation analysis revealed a significant relationship between the percentage of cytotoxic T cells and global cortical mean PiB-BPND . Hierarchical regression analyses showed that cytotoxic T cells were significantly related to the value of global cortical mean PiB-BPND and vice versa.<bold>Conclusions: </bold>Our results indicated that a specific peripheral immune response, reflected in the increased ratio of cytotoxic T cells, could be regarded as a preclinical sign of AD and could be attributed to the Aβ neuropathological mechanism. Copyright © 2017 John Wiley & Sons, Ltd.
- Subjects
CEREBRAL amyloid angiopathy; DEMENTIA; LYMPHOCYTES; COGNITION; ALZHEIMER'S disease; AMYLOID beta-protein; AMINES; CEREBRAL cortex; FLOW cytometry; MAGNETIC resonance imaging; PEPTIDES; T cells; THIAZOLES; POSITRON emission tomography
- Publication
International Journal of Geriatric Psychiatry, 2017, Vol 32, Issue 12, pe93
- ISSN
0885-6230
- Publication type
journal article
- DOI
10.1002/gps.4660