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- Title
Digit ratio (2D:4D) in Chinese women with breast cancer.
- Authors
Hong, Lu; Zhan‐Bing, Ma; Zhi‐Yun, Shi; Xiao‐Xia, Song; Jun‐Li, Zhao; Zheng‐Hao, Huo
- Abstract
ABSTRACT Objectives Digit ratio, especially second-to-fourth digit ratio (2D:4D) is established in utero and is positively correlated with oestrogen in men and women. It is a putative biomarker for prenatal hormone exposure and may represent an individual predisposition to certain diseases (e.g., breast cancer). The aim of the present study is to investigate whether there is a link between digit ratio (2D:4D) and breast cancer in Chinese populations. Methods The controls we chose were healthy subjects-age and -sex matched to the patients diagnosed with breast cancer. Photocopies of the two hands of 218 women (controls: 109; patients: 109) were collected. Left hand, right hand, mean hand, and right minus left 2D:4D (Dr−l) were analyzed. Results The patients with breast cancer presented significantly higher 2D:4D than controls (left: P < 0.01; right: P < 0.05; mean: P < 0.05). The mean values of 2D:4D on the left hand were significantly higher than those on the right hand in the two groups, respectively (controls: P < 0.05; patients: P ≤ 0.01). In patients, there was a significantly negative correlation between 2D:4D (left hand: P < 0.01; right hand, mean: P < 0.05) and the presented age with breast cancer, but no association between Dr−l and age of presented disease. Conclusions Digit ratio (2D:4D) may correlate with the increased risk of breast cancer. Am. J. Hum. Biol. 26:562-564, 2014. © 2014 Wiley Periodicals, Inc.
- Subjects
CHINESE women; BREAST cancer; ESTROGEN; BIOMARKERS; DISEASE susceptibility; HEALTH
- Publication
American Journal of Human Biology, 2014, Vol 26, Issue 4, p562
- ISSN
1042-0533
- Publication type
Article
- DOI
10.1002/ajhb.22546