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- Title
Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay.
- Authors
Hajizadeh, Mohammad Reza; Parvaz, Najmeh; Barani, Mahmood; Khoshdel, Alireza; Fahmidehkar, Mohammad Ali; Mahmoodi, Mehdi; Torkzadeh-Mahani, Masoud
- Abstract
Background: The use of phytochemicals to prevent or suppress tumours is known as chemoprevention. Numerous plant-derived agents have been reported to have anticancer potentials. As one such anticancer phytochemical, diosgenin has several applications which are nevertheless limited due to its low solubility in water. Methods: We loaded diosgenin into niosome to increase its solubility and hence efficiency. Diosgenin-niosome (diosgenin loaded into niosome) was prepared by thin-film hydration method and characterised by optical microscopy, dynamic light scattering (DLS), scanning electron microscopy (SEM), and UV-visible spectrophotometry. Also, loading efficiency, in vitro drug release, and cytotoxicity assay were performed on HepG2 cell line. Results and discussion: Diosgenin-niosome has a nanometric size with a normal size distribution and spherical morphology. The loading efficiency of diosgenin was about 89% with a sustainable and controllable release rate. Finally, the viability of free diosgenin was 61.25%, and after loading into niosomes, it was improved to 28.32%. Conclusion: The results demonstrated that niosomes increase the solubility of naturally derived hydrophobic chemicals and thus enhance their anticancer effect.
- Subjects
CELL lines; CELL surface antigens; PHYSICAL &; theoretical chemistry; DRUG delivery systems; DOSAGE forms of drugs; ELECTRON microscopy; HEPATOCELLULAR carcinoma; IMMUNODIAGNOSIS; ARTIFICIAL membranes; MICROSCOPY; NANOPARTICLES; SOLUBILITY; SPECTROPHOTOMETRY; STEROIDS; PHYTOCHEMICALS; TREATMENT effectiveness; DESCRIPTIVE statistics; IN vitro studies
- Publication
DARU: Journal of Pharmaceutical Sciences, 2019, Vol 27, p329
- ISSN
1560-8115
- Publication type
Article
- DOI
10.1007/s40199-019-00277-0