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- Title
Biological small-angle X-ray scattering facility at the Stanford Synchrotron Radiation Laboratory.
- Authors
Smolsky, Igor L.; Ping Liu; Niebuhr, Marc; Ito, Kazuki; Weiss, Thomas M.; Tsuruta, Hiro
- Abstract
Beamline 4-2 at the Stanford Synchrotron Radiation Laboratory is a small-angle X-ray scattering/diffraction facility dedicated to structural studies on mostly noncrystalline biological systems. The instrument consists of a pinhole camera, which covers the magnitude of the scattering vector Q in the range 0.004–1.3 Å−1 [ Q = (4π/λ)sin θ, where θ and λ are one half of the scattering angle and the X-ray wavelength, respectively], and a Bonse–Hart geometry ultra-small-angle X-ray scattering setup for the Q range an order of magnitude smaller. The pinhole camera allows quick automated distance and detector selection among any combination of five distances and three position-sensitive detectors. The double-crystal monochromator can have either Si 111 crystals or a pair of synthetic multilayer diffractive elements for higher flux applications. We have adopted a suite of software originally developed for macromolecular crystallography for integrated beamline control as well as static and slow time-resolved small-angle scattering data collection. This article outlines recent technological developments and specialized instrumentation for conducting noncrystalline scattering experiments in structural biology at improved time and spatial resolutions.
- Subjects
SMALL-angle X-ray scattering; ELECTROMAGNETIC waves; CRYSTALLOGRAPHY; SYNCHROTRONS; ENGINEERING instruments; BIOLOGICAL systems
- Publication
Journal of Applied Crystallography, 2007, Vol 40, ps453
- ISSN
0021-8898
- Publication type
Article
- DOI
10.1107/S0021889807009624