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- Title
Phthalates in the NICU: Is it safe?
- Authors
Fischer, Céline J; Bickle Graz, Myriam; Muehlethaler, Vincent; Palmero, David; Tolsa, Jean‐François
- Abstract
Aims As growing concerns exist regarding phthalate exposure, which could be teratogenic, carcinogenic or induce reproductive toxicity, we aimed to review the evidence of the risks due to the use of medical devices containing di(2-ethylhexyl)phthalate in hospitalized neonates. Methods We reviewed the literature, searching through medical literature databases (Pubmed, MEDLINE, EBM reviews, Cochrane database, Embase and Google Scholar) using the following keywords: phthalate, di(2-ethylhexyl)phthalate, newborn and neonate. Results We identified several associations with short and long term health dangers, mainly subfertility, broncho-pulmonary dysplasia, necrotising enterocolitis, parenteral nutrition associated cholestasis and neuro-developmental disorders. These data are based mainly on animal or observational human studies. Conclusion Clinicians must be aware of the potential risks due to phthalate exposure in the NICU. Di(2-ethylhexyl)phthalate containing materials should be identified and alternative devices should be considered. There is a need to improve knowledge in this area.
- Subjects
PHTHALATE esters; NEONATAL intensive care; PHYSIOLOGICAL effects of plasticizers; CARCINOGENS research; MEDICAL equipment safety measures
- Publication
Journal of Paediatrics & Child Health, 2013, Vol 49, Issue 9, pE413
- ISSN
1034-4810
- Publication type
Article
- DOI
10.1111/jpc.12244