We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Direct Synthesis of Disubstituted 3‐Isoquinolinone Derivatives through the Construction of C−N, C=O, and C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bonds under Transition‐Metal‐Free Conditions.
- Authors
Shi, Jianyi; Chen, Xia; Huang, Jingyun; Lu, Yantong; Yang, Zhendong; Zhong, Mingli; Zhu, Zhongzhi; Chen, Xiuwen
- Abstract
The efficient three‐component cascade coupling reaction of 3‐haloisoquinolines, haloalkanes, and sp3‐carbon nucleophiles (acetophenone or nitromethane) led to a series of structurally novel 1,2‐disubstituted‐3‐isoquinolinones through the formation of C(sp3)−C(sp2), C−N, and C=O bonds. The NaOAc‐promoted reaction described in this work is simple to operate, environment friendly, and highly selective.
- Subjects
NITROMETHANE; ACETOPHENONE; HALOALKANES; NUCLEOPHILES
- Publication
European Journal of Organic Chemistry, 2023, Vol 26, Issue 3, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202201231