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- Title
The renal handling of beta[SUB2]-microglobulin in the dog.
- Authors
Hall III, Philip W.; Moon Chung-Park; Vacca, Christina V.; London, Michael; Crowley, Andrea Q.
- Abstract
The renal extraction of beta2-microglobulin (β2M) was investigated under steady-state conditions achieved by constant infusion of human β2M. Fifteen animal experiments were conducted. Beta2 microglobulin was infused at rates ranging from 51 to 269 µg/min. The renal arterial and venous blood levels remained constant throughout the study period. The data showed that renal extraction of β2M exceeded the rate of filtration at all levels of β2M delivered to the kidney. The tubular uptake of filtered β2M increased linearly as did the extraglomerular extraction throughout the range investigated. There was no evidence that either mechanism was saturated. The fractional excretion of β2M (FE β2M) increased linearly with the fractional excretion of filtered water (FE H2O). The results are interpreted to indicate that β2M is extracted from renal blood by glomerular filtration and, in addition, by a mechanism independent of glomerular filtration rate (GFR). Under the conditions existing in these experimental animals, the linear relationship between FE β2M and FE H2O is evidence to suggest that factors affecting proximal tubular water reabsorption also affect β2M reabsorption.
- Subjects
GLOBULINS; KIDNEY blood-vessels; KIDNEYS; EXCRETION; KIDNEY glomerulus; KIDNEY tubules
- Publication
Kidney International, 1982, Vol 22, Issue 2, p156
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1982.147