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- Title
High-resolution Peripheral Quantitative Computed Tomography Imaging in the Assessment of Periarticular Bone of Metacarpophalangeal and Wrist Joints.
- Authors
Nagaraj, Sujay; Finzel, Stephanie; Stok, Kathryn S.; Barnabe, Cheryl; SPECTRA Collaboration
- Abstract
<bold>Objective: </bold>To synthesize descriptions of periarticular findings at the metacarpophalangeal (MCP) and wrist joints in different types of arthritis and in the normal state imaged by high-resolution peripheral quantitative computed tomography (HR-pQCT); to assemble the literature reporting on the ability of HR-pQCT to detect findings relative to other imaging modalities; and to collate results on the reproducibility of image interpretation.<bold>Methods: </bold>A systematic literature review was performed using terms for HR-pQCT and MCP or wrist joints using medical literature databases and conference abstracts. Any study describing predefined pathology findings, comparison to another radiographic technique, or a measure of reproducibility was included with no limitation by disease state.<bold>Results: </bold>We identified 44 studies meeting inclusion criteria from the 1901 articles identified by our search. All 44 reported on pathology findings, including erosions (n = 31), bone microarchitecture (n = 10) and bone mineral density (n = 10) variables, joint space evaluation (n = 7), or osteophyte characterization (n = 7). Seventeen of the studies compared HR-pQCT findings to either plain radiography (n = 9), ultrasound (n = 4), magnetic resonance imaging (n = 5), or microcomputed tomography (n = 2), with HR-pQCT having high sensitivity for erosion detection. Twenty-four studies included an assessment of reproducibility with good to excellent metrics, and highlighting the critical importance of positioning when assessing joint space variables.<bold>Conclusion: </bold>Despite high sensitivity for erosion detection and good reproducibility, more research is required to determine where HR-pQCT can be applied to enhance our understanding of periarticular bone changes in a variety of arthritis conditions.
- Subjects
BONES; COMPUTED tomography; MAGNETIC resonance imaging; WRIST; SYSTEMATIC reviews; BONE density; METACARPOPHALANGEAL joint
- Publication
Journal of Rheumatology, 2016, Vol 43, Issue 10, p1921
- ISSN
0315-162X
- Publication type
journal article
- DOI
10.3899/jrheum.160647