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- Title
Novel Two-Stage Fine Milling Enables High-Throughput Determination of Glyphosate Residues in Raw Agricultural Commodities.
- Authors
RITER, LEAH S.; WUJCIK, CHAD E.
- Abstract
Dramatic process-efficiency gains for residue analysis of glyphosate in raw agricultural commodities (RACs) were achieved by development and validation of a two-stage finemilling process. This secondary milling produced a uniform and consistent product that could be reproducibly measured with 75 mg analytical test portions. The milligram scale sample size enabled the direct weighing of sample into a liquid-handlercompatible 96-well format. A high-throughput workflow based on this innovative comminution approach for the quantitation of glyphosate, a nonselective herbicide, and its main degradation product, aminomethylphosphonic acid, was validated in various RACs and used to demonstrate the applicability of the two-step milling process. The precision and reproducibility of 75 mg analytical portions taken through this assay was used to demonstrate the feasibility of using a twostage fine-milling technique for pesticide residue applications. An RSD of less than 10% was achieved in endogenous glyphosate residues in multiple RACs. Comparable recoveries and superior precision were achieved with this new method as compared with a validated 10 g scale method.
- Subjects
GLYPHOSATE; FARM produce; HERBICIDE toxicology; HERBICIDE residues; FOOD safety
- Publication
Journal of AOAC International, 2018, Vol 101, Issue 3, p867
- ISSN
1060-3271
- Publication type
Article
- DOI
10.5740/jaoacint.17-0317