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- Title
Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na, K-ATPase.
- Authors
Ianiski, Francine; Alves, Catiane; Ferreira, Carla; Rech, Virginia; Savegnago, Lucielli; Wilhelm, Ethel; Luchese, Cristiane
- Abstract
The objective of this study was to investigate the effect of meloxicam-loaded nanocapsules (M-NC) on the treatment of the memory impairment induced by amyloid β-peptide (aβ) in mice. The involvement of Na, K-ATPase and cyclooxygenase-2 (COX-2) activities in the hippocampus and cerebral cortex was also evaluated. Mice received aβ (3 nmol/ 3 μl/ per site, intracerebroventricular) or vehicle (3 μl/ per site, i.c.v.). The next day, the animals were treated with blank nanocapsules (17 mL/kg) or M-NC (5 mg/kg) or free meloxicam (M-F) (5 mg/kg). Treatments were performed every other day, until the twelfth day. Animals were submitted to the behavioral tasks (open-field, object recognition, Y-maze and step-down inhibitory avoidance tasks) from the twelfth day. Na, K-ATPase and COX-2 activities were performed in hippocampus and cerebral cortex. aβ caused a memory deficit, an inhibition of the hippocampal Na, K-ATPase activity and an increase in the hippocampal COX-2 activity. M-NC were effective against all behavioral and biochemical alterations, while M-F restored only the COX-2 activity. In conclusion, M-NC were able to reverse the memory impairment induced by aβ, and Na, K-ATPase is involved in the effect of M-NC.
- Subjects
ALZHEIMER'S disease; BASAL ganglia diseases; CYCLOOXYGENASES; AMYLOID; GLYCOPROTEINS; LABORATORY mice
- Publication
Metabolic Brain Disease, 2016, Vol 31, Issue 4, p793
- ISSN
0885-7490
- Publication type
Article
- DOI
10.1007/s11011-016-9812-3