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- Title
Intrauterine undernutrition—renal and vascular origin of hypertension
- Authors
Franco, Maria do Carmo Pinho; Nigro, Dorothy; Fortes, Zuleica B.; Tostes, Rita C.A.; Carvalho, Maria Helena C.; Lucas, Sandra Regina Rodrigues; Gomes, Guiomar Nascimento; Coimbra, Terezila Machado; Gil, Frida Zaladek
- Abstract
Objective: A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.
- Subjects
INTRAUTERINE blood transfusion; MALNUTRITION; BIRTH weight; HYPERTENSION
- Publication
Cardiovascular Research, 2003, Vol 60, Issue 2, p228
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1016/S0008-6363(03)00541-8