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- Title
Sensibilidad in vitro a amoxicilina y claritromicina de Helicobacter pylori obtenido de biopsias gástricas de pacientes en zona de bajo riesgo para cáncer gástrico.
- Authors
Figueroa, Mercedes; Cortés, Armando; Pazos, Álvaro; Bravo, Luis Eduardo
- Abstract
Introduction. Infection by Helicobacter pylori is prevalent in approximately half the world's population. However, the susceptibility of H. pylori to antimicrobial agents must be evaluated by in vitro methods in order to determine the susceptibility levels and to guide treatment regimes. Objective. The prevalence of infection and antibiotic susceptibility was evaluated in gastric biopsies containing H. pylori. Materials and methods. The prevalence of infection and antibiotic susceptibility was investigated in 203 patients with chronic gastritis from Tumaco, Colombia. Diagnosis was confirmed by histopathological evidence (Dixon scale) and microbiological (culture on blood agar supplemented with antibiotics). The antibiotic resistance of H. pylori was measured by its response to antimicrobial amoxicillin and clarithromycin using the agar dilution method. Results. The prevalence of infection for H. pylori with histopathological and microbiological tests was 88.7% and 84.7% respectively. The prevalence of resistance of H. pylori to antimicrobial amoxicillin was 20.5%, to clarithromycin 19.8%, and to both antibiotics concurrently, 10.9%.
- Subjects
TREATMENT of helicobacter pylori infections; ANTI-infective agents; DISEASE prevalence; DISEASE susceptibility; HISTOPATHOLOGY; DRUG resistance; BLOOD agar
- Publication
Biomédica: Revista del Instituto Nacional de Salud, 2012, Vol 32, Issue 1, p32
- ISSN
0120-4157
- Publication type
Article