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- Title
Assessment of the sedative effects of buprenorphine administered with 20 µg/kg detomidine in horses.
- Authors
Love, E. J.; Taylor, P. M.; Murrell, J.; Whay, H. R.; Waterman-Pearson, A. E.
- Abstract
The aim of this randomised, observer-blinded, crossover study was to compare the effects of four treatments, administered intravenously to six horses: saline and saline; 10 µg/kg detomidine and 7.5 µg/kg buprenorphine; 20 µg/kg detomidine and 7.5 µg/kg buprenorphine; and 20 µg/kg detomidine and 10 µg/kg buprenorphine. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation and duration of sedation were investigated using a univariate general linear model with post-hoc Tukey tests (P<0.05). Increasing the dose of detomidine from 10 to 20 µg/kg increased the degree of sedation when administered with the same dose of buprenorphine (7.5 µg/kg). When administered with 20 µg/kg detomidine, increasing the dose of buprenorphine from 7.5 to 10 µg/kg did not influence the degree of sedation achieved.
- Subjects
HORSES; BUPRENORPHINE; ANALGESICS; ANIMAL sedation; MORPHINE derivatives
- Publication
Veterinary Record: Journal of the British Veterinary Association, 2011, Vol 168, Issue 15, p408
- ISSN
0042-4900
- Publication type
Article
- DOI
10.1136/vr.c7315