We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation.
- Authors
Khan, Shahida A.; Ali, Ashraf; Khan, Sarah A.; Zahran, Solafa A.; Damanhouri, Ghazi; Azhar, Esam; Qadri, Ishtiaq
- Abstract
Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few. Increases in mortality and morbidity in obesity related inflammation have initiated studies to explore different lipid mediated molecular pathways of attempting resolution that uncover newer therapeutic opportunities of anti-inflammatory components. Majorly the thromboxanes, prostaglandins, leukotrienes, lipoxins, and so forth form the group of lipid mediators influencing inflammation. Of special mention are the omega-6 and omega-3 fatty acids that regulate inflammatory mediators of interest in hepatocytes and adipocytes via the cyclooxygenase and lipoxygenase pathways. They also exhibit profound effects on eicosanoid production.The inflammatory cyclooxygenase pathway arising fromarachidonic acid is a critical step in the progression of inflammatory responses. New oxygenated products of omega-3 metabolism, namely, resolvins and protectins, behave as endogenous mediators exhibiting powerful anti-inflammatory and immune-regulatory actions via the peroxisome proliferator-activated receptors (PPARs) and G protein coupled receptors (GPCRs). In this review we attempt to discuss the complex pathways and links between obesity and inflammation particularly in relation to different lipid mediators.
- Subjects
OBESITY; INFLAMMATION; LIPIDS; METABOLIC disorders; THROMBOXANES; LEUKOTRIENES
- Publication
Mediators of Inflammation, 2014, Vol 2014, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2014/502749