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- Title
Cell therapy for type 1 diabetes.
- Authors
Muir, K.R.; Lima, M.J.; Docherty, H.M.; Docherty, K.
- Abstract
Cell therapy in the form of human islet transplantation has been a successful form of treatment for patients with type 1 diabetes for over 10 years, but is significantly limited by lack of suitable donor material. A replenishable supply of insulin-producing cells has the potential to address this problem; however to date success has been limited to a few preclinical studies. Two of the most promising strategies include differentiation of embryonic stem cells and induced pluripotent stem cells towards insulin-producing cells and transdifferentiation of acinar or other closely related cell types towards β-cells. Here, we discuss recent progress and challenges that need to be overcome in taking cell therapy to the clinic.
- Subjects
TREATMENT of diabetes; TYPE 1 diabetes; CELLULAR therapy; ISLANDS of Langerhans transplantation; CELL differentiation; EMBRYONIC stem cells; PLURIPOTENT stem cells
- Publication
QJM: An International Journal of Medicine, 2014, Vol 107, Issue 4, p253
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcu025