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- Title
Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease.
- Authors
A.G. Rumley; M. Woodward; A. Rumley; J. Rumley; G.D.O. Lowe
- Abstract
Background: The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined.Aim: To study the relationships of plasma lipid peroxides to cardiovascular risk factors in a random population sample.Design: Random, age- and sex-stratified population sample.Methods: We studied 739 men and women aged 2574 years. Lipid peroxides were assayed by the thiobarbituric acid (TBA) assay for malondialdehyde (MDA) in stored plasma samples.Results: Lipid peroxide levels increased with age. In men, lipid peroxides were significantly associated with smoking habit. Lipid peroxides correlated with non-fasting serum triglycerides (r = 0.33; p < 0.0001) in both sexes. Weaker associations were observed for cholesterol, high-density lipoprotein cholesterol (inversely), body mass index, fibrinogen and white cell count; as well as an inverse association with serum vitamin C in men.Discussion: These findings clarify the relationships of plasma lipid peroxides to cardiovascular risk factors; and are consistent with the hypothesis that lipid peroxidation may be one mechanism through which several risk factors may promote cardiovascular disease.
- Subjects
BLOOD plasma; ISOPENTENOIDS; BODY weight; CARDIOVASCULAR diseases
- Publication
QJM: An International Journal of Medicine, 2004, Vol 97, Issue 12, p809
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hch130