We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chronic and Acute Effects of Coal Tar Pitch Exposure and Cardiopulmonary Mortality Among Aluminum Smelter Workers.
- Authors
Friesen, Melissa C.; Demers, Paul A.; Spinelli, John J.; Eisen, Ellen A.; Lorenzi, Maria F.; Le, Nhu D.
- Abstract
Air pollution causes several adverse cardiovascular and respiratory effects. In occupational studies, where levels of particulate matter and polycyclic aromatic hydrocarbons (PAHs) are higher, the evidence is inconsistent. The effects of acute and chronic PAH exposure on cardiopulmonary mortality were examined within a Kitimat, Canada, aluminum smelter cohort (n = 7,026) linked to a national mortality database (1957–1999). No standardized mortality ratio was significantly elevated compared with the province's population. Smoking-adjusted internal comparisons were conducted using Cox regression for male subjects (n = 6,423). Ischemic heart disease (IHD) mortality (n = 281) was associated with cumulative benzo[a]pyrene (B(a)P) exposure (hazard ratio = 1.62, 95% confidence interval: 1.06, 2.46) in the highest category. A monotonic but nonsignificant trend was observed with chronic B(a)P exposure and acute myocardial infarction (n = 184). When follow-up was restricted to active employment, the hazard ratio for IHD was 2.39 (95% confidence interval: 0.95, 6.05) in the highest cumulative B(a)P category. The stronger associations observed during employment suggest that risk may not persist after exposure cessation. No associations with recent or current exposure were observed. IHD was associated with chronic (but not current) PAH exposure in a high-exposure occupational setting. Given the widespread workplace exposure to PAHs and heart disease's high prevalence, even modest associations produce a high burden.
- Subjects
COAL-tar colors; CARDIOPULMONARY system; DISEASES; ALUMINUM industry; AIR pollution; HEART disease related mortality; OCCUPATIONAL diseases; PHYSIOLOGICAL effects of polycyclic aromatic hydrocarbons
- Publication
American Journal of Epidemiology, 2010, Vol 172, Issue 7, p790
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwq208