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- Title
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
- Authors
Sha Mi; Bing Hu; Kyungmin Hahm; Yi Luo; Kam Hui, Edward Sai; Qiuju Yuan; Wai Man Wong; Li Wang; Huanxing Su; Tak-Ho Chu; Jiasong Guo; Wenming Zhang; Kwok-Fai So; Pepinsky, Blake; Zhaohui Shao; Graff, Christilyn; Garber, Ellen; Jung, Vincent; Ed Xuekui Wu; Wutian Wu
- Abstract
Demyelinating diseases, such as multiple sclerosis, are characterized by the loss of the myelin sheath around neurons, owing to inflammation and gliosis in the central nervous system (CNS). Current treatments therefore target anti-inflammatory mechanisms to impede or slow disease progression. The identification of a means to enhance axon myelination would present new therapeutic approaches to inhibit and possibly reverse disease progression. Previously, LRR and Ig domain–containing, Nogo receptor–interacting protein (LINGO-1) has been identified as an in vitro and in vivo negative regulator of oligodendrocyte differentiation and myelination. Here we show that loss of LINGO-1 function by Lingo1 gene knockout or by treatment with an antibody antagonist of LINGO-1 function leads to functional recovery from experimental autoimmune encephalomyelitis. This is reflected biologically by improved axonal integrity, as confirmed by magnetic resonance diffusion tensor imaging, and by newly formed myelin sheaths, as determined by electron microscopy. Antagonism of LINGO-1 or its pathway is therefore a promising approach for the treatment of demyelinating diseases of the CNS.
- Subjects
SPINAL cord diseases; AUTOIMMUNE diseases; ENCEPHALOMYELITIS; CENTRAL nervous system diseases; MULTIPLE sclerosis
- Publication
Nature Medicine, 2007, Vol 13, Issue 10, p1228
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1664