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- Title
NADPH:Quinone Oxidoreductase-1 as a New Regulatory Enzyme That Increases Melanin Synthesis.
- Authors
Yamaguchi, Yuji; Hearing, Vincent J.; Maeda, Akira; Morita, Akimichi
- Abstract
Most hypopigmenting reagents target the inhibition of tyrosinase, the key enzyme involved in melanin synthesis. In this issue, Choi et al. report that NADPH:quinone oxidoreductase-1 (NQO1) increases melanin synthesis, probably via the suppression of tyrosinase degradation. Because NQO1 was identified by comparing normally pigmented melanocytes with hypopigmented acral lentiginous melanoma cells, these results suggest various hypotheses regarding the carcinogenic origin of the latter.
- Subjects
OXIDOREDUCTASES; MELANOGENESIS; TYROSINE; PHENOL oxidase; MELANOMA; CARCINOGENICITY
- Publication
Journal of Investigative Dermatology, 2010, Vol 130, Issue 3, p645
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2009.378