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- Title
iNOSpromoter variants and severe malaria in Ghanaian children.
- Authors
Cramer, Jakob P.; Mockenhaupt, Frank P.; Ehrhardt, Stephan; Burkhardt, Jana; Otchwemah, Rowland N.; Dietz, Ekkehardt; Gellert, Sabine; Bienzle, Ulrich
- Abstract
Nitric oxide is an important mediator in the host defence againstPlasmodium falciparummalaria. It has antiparasitic effectsin vitro. However, its role in clinical disease remains controversial. Polymorphisms in the inducible nitric oxide synthase promoter (iNOS;−954G→C,−1173C→T,−2.6 kb CCTTT(n) microsatellite) may influence susceptibility to and severity of malaria. We tested this hypothesis in a case–control study among Ghanaian children with severe malaria (SM) and asymptomatic parasitaemia, respectively, and in healthy controls. In this study, the respective frequencies ofiNOS−954G→C and−1173C→T did not differ between groups but≥13 microsatellite copies were associated with SM.−954G→C and−1173C→T were in linkage disequilibrium with CCTTT(8) and CCTTT(13), respectively.−954G→C/CCTTT(8) protected against hyperparasitaemia whereas−1173C→T/CCTTT(13) increased fatality. These findings suggest thatiNOSpromoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children.
- Subjects
GHANA; MALARIA; NITRIC oxide; PLASMODIUM falciparum; BIOLOGY; MICROSATELLITE repeats
- Publication
Tropical Medicine & International Health, 2004, Vol 9, Issue 10, p1074
- ISSN
1360-2276
- Publication type
Article
- DOI
10.1111/j.1365-3156.2004.01312.x