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- Title
Ifosfamide, cisplatin and etoposide combination in locally advanced inoperable non-small-cell lung cancer: a phase II study.
- Authors
Scinto, A F; Ferraresi, V; Milella, M; Tucci, E; Santomaggio, C; Pasquali-Lasagni, R; Vecchio, M R Del; Campioni, N; Nardi, M; Cognetti, F
- Abstract
From March 1993 to February 1997, 43 eligible patients with inoperable stage IIIA (ten patients) and stage IIIB (33 patients), histologically confirmed NSCLC received 3 courses of the ICE combination (ifosfamide 1.5 g m[SUP-2] and mesna 750 mg m[SUP-2] two times a day, cisplatin 25 mg m[SUP-2] and etoposide 100 mg m[SUP-2], all administered intravenously (i.v.) on days 1-3 every 3 weeks) with G-CSF support. After three cycles, patients were submitted to radical surgery or received two additional courses of the ICE regimen and/or curative radiotherapy. Grade 3-4 neutropenia occurred in 21% of 114 evaluable courses, but was of short duration, leading to neutropenic fever in 5% of the courses. Severe thrombocytopenia and anaemia were observed in 13% and 3% of the courses respectively. Non-haematological toxicity was generally mild with only two episodes of reversible renal impairment. The overall response rate after three chemotherapy courses was 69% (28 partial responses, one complete response). Ten patients (8/10 patients in stage IIIA, 2/33 patients in stage IIIB) underwent radical surgery. Median TTP for patients not undergoing surgery (n = 33) was 8 months (range 3-34+); median DFS for patients rendered NED by surgery (n = 10) was 26 months (range 1-54+). Median OS for the entire group was 12.5 months (range 2-57+). The ICE regimen is active in locally advanced NSCLC with acceptable toxicity and warrants further exploration as induction chemotherapy in larger series.
- Subjects
CISPLATIN; LUNG cancer
- Publication
British Journal of Cancer, 1999, Vol 81, Issue 6, p1031
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/sj.bjc.6690803