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Challenges and approaches for the development of safer immunomodulatory biologics.
- Published in:
- Nature Reviews Drug Discovery, 2013, v. 12, n. 4, p. 306, doi. 10.1038/nrd3974
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- Article
Managing the challenge of chemically reactive metabolites in drug development.
- Published in:
- 2011
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- Publication type:
- journal article
Immunological Principles of Adverse Drug Reactions.
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- Drug Safety, 2000, v. 23, n. 6, p. 483, doi. 10.2165/00002018-200023060-00002
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- Publication type:
- Article
Trimethoprim-induced aseptic meningism.
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- British Journal of Hospital Medicine (17508460), 2017, v. 78, n. 2, p. 108, doi. 10.12968/hmed.2017.78.2.108
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- Publication type:
- Article
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo.
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- British Journal of Pharmacology, 2001, v. 133, n. 2, p. 295, doi. 10.1038/sj.bjp.0704074
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- Publication type:
- Article
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells.
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- British Journal of Pharmacology, 2001, v. 132, n. 3, p. 623, doi. 10.1038/sj.bjp.0703845
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- Article
Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.
- Published in:
- 1999
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- Publication type:
- journal article
Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.
- Published in:
- NPJ Vaccines, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41541-024-00895-z
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- Publication type:
- Article
Drug hapten‐specific T‐cell activation: Current status and unanswered questions.
- Published in:
- Proteomics, 2021, v. 21, n. 17/18, p. 1, doi. 10.1002/pmic.202000267
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- Publication type:
- Article
The Generation, Detection, and Effects of Reactive Drug Metabolites.
- Published in:
- Medicinal Research Reviews, 2013, v. 33, n. 5, p. 985, doi. 10.1002/med.21273
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- Publication type:
- Article
T‐cell‐mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis.
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- Pediatric Allergy & Immunology, 2022, v. 33, n. 6, p. 1, doi. 10.1111/pai.13815
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- Publication type:
- Article
Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01.
- Published in:
- Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.658593
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- Publication type:
- Article
Characterization of p-Phenylenediamine–Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein.
- Published in:
- Journal of Investigative Dermatology, 2010, v. 130, n. 3, p. 732, doi. 10.1038/jid.2009.271
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- Publication type:
- Article
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals.
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- Journal of Investigative Dermatology, 2010, v. 130, n. 1, p. 161, doi. 10.1038/jid.2009.187
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- Publication type:
- Article
Activation of T-Cells from Allergic Patients and Volunteers by p-Phenylenediamine and Bandrowski's Base.
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- Journal of Investigative Dermatology, 2008, v. 128, n. 4, p. 897, doi. 10.1038/sj.jid.5701071
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- Publication type:
- Article
Metabolism of lamotrigine to a chemically reactive metabolite(s) in vivo: possible role in cutaneous reactions.
- Published in:
- British Journal of Clinical Pharmacology, 1999, v. 48, n. 6, p. 876P
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- Publication type:
- Article
Glycolysis: An early marker for vancomycin‐specific T‐cell activation.
- Published in:
- Clinical & Experimental Allergy, 2024, v. 54, n. 1, p. 21, doi. 10.1111/cea.14423
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- Article
Pathology of drug hypersensitivity reactions and mechanisms of immune tolerance.
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- Clinical & Experimental Allergy, 2022, v. 52, n. 12, p. 1379, doi. 10.1111/cea.14235
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- Publication type:
- Article
Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications?
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- Clinical & Experimental Allergy, 2022, v. 52, n. 5, p. 600, doi. 10.1111/cea.14134
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- Publication type:
- Article
Patients with naproxen‐induced liver injury display T‐cell memory responses toward an oxidative (S)‐O‐desmethyl naproxen metabolite but not the acyl glucuronide.
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- Allergy, 2024, v. 79, n. 1, p. 200, doi. 10.1111/all.15830
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- Publication type:
- Article
Drug‐specific T‐cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat.
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- Allergy, 2021, v. 76, n. 6, p. 1825, doi. 10.1111/all.14652
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- Article
Characterization of amoxicillin and clavulanic acid specific T‐cell clones from patients with immediate drug hypersensitivity.
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- Allergy, 2020, v. 75, n. 10, p. 2562, doi. 10.1111/all.14298
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- Publication type:
- Article
Immune dysregulation increases the incidence of delayed‐type drug hypersensitivity reactions.
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- Allergy, 2020, v. 75, n. 4, p. 781, doi. 10.1111/all.14127
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- Publication type:
- Article
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation.
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- Allergy, 2020, v. 75, n. 3, p. 636, doi. 10.1111/all.14057
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- Publication type:
- Article
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01.
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- Allergy, 2019, v. 74, n. 8, p. 1533, doi. 10.1111/all.13769
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- Publication type:
- Article
Immune checkpoint blockade lowers the threshold of naïve T-cell priming to drug-associated antigens in a dose-dependent fashion.
- Published in:
- Toxicological Sciences, 2024, v. 202, n. 1, p. 13, doi. 10.1093/toxsci/kfae118
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- Publication type:
- Article
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment.
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- Toxicological Sciences, 2024, v. 197, n. 1, p. 38, doi. 10.1093/toxsci/kfad101
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- Article
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
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- Toxicological Sciences, 2023, v. 192, n. 1, p. 106, doi. 10.1093/toxsci/kfad015
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- Publication type:
- Article
Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01.
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- Toxicological Sciences, 2021, v. 183, n. 1, p. 139, doi. 10.1093/toxsci/kfab084
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- Publication type:
- Article
Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite.
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- Toxicological Sciences, 2021, v. 179, n. 1, p. 95, doi. 10.1093/toxsci/kfaa157
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- Publication type:
- Article
HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts.
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- Toxicological Sciences, 2020, v. 178, n. 1, p. 115, doi. 10.1093/toxsci/kfaa128
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- Publication type:
- Article
Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation.
- Published in:
- Toxicological Sciences, 2020, v. 177, n. 2, p. 454, doi. 10.1093/toxsci/kfaa124
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- Publication type:
- Article
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.
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- Toxicological Sciences, 2020, v. 175, n. 2, p. 266, doi. 10.1093/toxsci/kfaa034
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- Publication type:
- Article
Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers.
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- Toxicological Sciences, 2019, v. 168, n. 2, p. 597, doi. 10.1093/toxsci/kfz007
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- Publication type:
- Article
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.
- Published in:
- Toxicological Sciences, 2017, v. 158, n. 1, p. 76, doi. 10.1093/toxsci/kfx069
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- Publication type:
- Article
Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury.
- Published in:
- Toxicological Sciences, 2017, v. 155, n. 2, p. 420, doi. 10.1093/toxsci/kfw218
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- Publication type:
- Article
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
- Published in:
- Toxicological Sciences, 2016, v. 154, n. 2, p. 416, doi. 10.1093/toxsci/kfw177
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- Publication type:
- Article
Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis.
- Published in:
- Toxicological Sciences, 2016, v. 154, n. 1, p. 5, doi. 10.1093/toxsci/kfw140
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- Publication type:
- Article
Activation of Flucloxacillin-Specific CD81 T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.
- Published in:
- Toxicological Sciences, 2015, v. 146, n. 1, p. 146, doi. 10.1093/toxsci/kfv077
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- Publication type:
- Article
The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs.
- Published in:
- Toxicological Sciences, 2012, v. 127, n. 1, p. 150, doi. 10.1093/toxsci/kfs080
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- Publication type:
- Article
HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp.
- Published in:
- Clinical & Experimental Dermatology, 2023, v. 48, n. 11, p. 1260, doi. 10.1093/ced/llad282
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- Publication type:
- Article