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- Title
Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006.
- Authors
Jia, Hao; Wu, Li; Liu, Rongrong; Li, Jialin; Liu, Lingling; Chen, Chen; Li, Junsen; Zhang, Kai; Liao, Junjiang; Long, Yuhua
- Abstract
One previously undescribed alkaloid, named penifuranone A (1), and three known compounds (2–4) were isolated from the mangrove endophytic fungus Penicillium crustosum SCNU-F0006. The structure of the new alkaloid (1) was elucidated based on extensive spectroscopic data analysis and single-crystal X-ray diffraction analysis. Four natural isolates and one new synthetic derivative of penifuranone A, compound 1a, were screened for their antimicrobial, antioxidant, and anti-inflammatory activities. Bioassays revealed that penifuranone A (1) exhibited strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 42.2 μM. The docking study revealed that compound 1 exhibited an ideal fit within the active site of the murine inducible nitric oxide synthase (iNOS), establishing characteristic hydrogen bonds.
- Subjects
ENDOPHYTIC fungi; NITRIC-oxide synthases; PENICILLIUM; MANGROVE plants; ANTI-inflammatory agents; ALKALOIDS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 9, p5032
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25095032