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- Title
Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment.
- Authors
Izadi, Farhad; Szczyrba, Adrian; Datta, Magdalena; Ciupak, Olga; Demkowicz, Sebastian; Rak, Janusz; Denifl, Stephan
- Abstract
When modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, and 5-bromo-4-thio-2′-deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry was used to detect the anionic products of dissociative electron attachment (DEA), and the experimental results were supported by quantum chemical calculations performed at the M062X/aug-cc-pVTZ level of theory. Experimentally, we found that BrSU predominantly captures low-energy electrons with kinetic energies near 0 eV, though the abundance of bromine anions was rather low compared to a similar experiment with bromouracil. We suggest that, for this reaction channel, proton-transfer reactions in the transient negative ions limit the release of bromine anions.
- Subjects
DEOXYRIBOSE; PROTON transfer reactions; ELECTRON kinetic energy; MOIETIES (Chemistry); ELECTRONS; URACIL derivatives
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 10, p8706
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24108706