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- Title
Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.
- Authors
Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Dimou, Niki L.; Pantavou, Katerina G.; Bagos, Pantelis G.; Mensah, Benedicta; Talias, Michael; Braliou, Georgia G.; Paraskeva, Dimitra; Bonovas, Stefanos; Hatzakis, Angelos
- Abstract
Some subjects are repeatedly exposed to human immunodeficiency virus (HIV), yet they remain uninfected. This suggests the existence of host-resistance mechanisms. The current study synthesizes the evidence regarding the association between interleukin (IL) gene polymorphisms and HIV susceptibility. Medline, Scopus and the Web of Science databases were systematically searched, and a meta-analysis of case-control studies was conducted. Univariate and bivariate methods were used. The literature search identified 42 eligible studies involving 15,727 subjects. Evidence was obtained on eight single-nucleotide polymorphisms (SNPs): <italic>IL1A</italic> −889 C>T (rs1800587), <italic>IL1B</italic> +3953/4 C>T (rs1143634), <italic>IL4</italic> −589/90 C>T (rs2243250), <italic>IL6</italic> −174 G>C (rs1800795), <italic>IL10</italic> −592 C>A (rs1800872), <italic>IL10</italic>−1082 A>G (rs1800896), <italic>IL12B</italic> −1188 A>C (rs3212227) and <italic>IL28B</italic> C>T (rs12979860). The <italic>IL1B</italic> +3953/4 C>T variant appears to increase the risk of HIV acquisition, under the assumption of a recessive genetic model (odds ratio (OR): 4.47, 95% CI: 2.35-8.52). The AA homozygotes of the <italic>IL10</italic> -592 C>A SNP had an increased, marginally nonsignificant, risk (OR: 1.39, 95% CI: 0.97-2.01). It reached, however, significance in subanalyses (OR: 1.49, 95% CI: 1.04-2.12). Finally, the well-studied hepatitis C virus (HCV) infection <italic>IL28B</italic> (rs12979860) CT/TT genotypes were associated with a 27% decrease in HIV infection risk, especially in populations infected with HCV (OR: 0.73, 95% CI: 0.57-0.95). Interleukin signalling is perhaps important in HIV infection and some interleukin genetic variants may affect the risk of HIV acquisition. Approaches targeting specific genes and genomewide association studies should be conducted to decipher the effect of these polymorphisms.
- Subjects
HIV; META-analysis; INTERLEUKIN receptors; GENETIC polymorphisms; HEPATITIS C virus
- Publication
Journal of Genetics, 2018, Vol 97, Issue 1, p235
- ISSN
0022-1333
- Publication type
Article
- DOI
10.1007/s12041-018-0907-y