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- Title
Western diet and lifestyle risk factors and colon crypt expression of TGFα, TGFβ<sub>1</sub>, and TGFβRII in the Markers of Adenomatous Polyps II case-control study.
- Authors
Daniel, Carrie Rose; Gonzalez-Feliciano, Amparo; Fedirko, Veronika; Dash, Chiranjeev; Shaukat, Aasma; Bostick, Roberd M.
- Abstract
We examined whether normal colorectal tissue expression of TGFα and TGFβ1, potent autocrine/paracrine growth factors, and TGFβ receptor 11 (TGFβRII), a mediator of TGFβ signaling, are modulated by dietary factors in a feasibility study. In a random sample of 25 cases and 25 controls from a colonoscopy-based case-control study (n=200) of biomarkers of incident colorectal adenoma, we measured expression of growth factors in normal-appearing rectal tissue using automated immunohistochemistry and image analysis. Diet was assessed with a Willett FFQ. Proportional differences in mean levels of TGFα, TGFβ1, TGFβRII, and the TGFα:TGFβ1 and TGFβ1:TGFβRII ratios in cases vs. controls, were 77.4%, 25.4%, -7.7%, 141%, and -7.9%, respectively. Expression of TGFα was statistically significantly associated with mono:saturated fat ratio, alcohol and NSAID use; TGFβ1 with estimated energy balance, fiber and sucrose intake; TGFβRII with an oxidative stress score, total energy intake (TEI), saturated fat, fiber, vitamin D, and zinc intake; TGFα:TGFβ1 with overweight (BMI≥25), TEI, and sucrose intake; and TGFβ1:TGFβRII with mono:saturated fat ratio, obesity (BMI≥30), and TEI. These results suggest that autocrine/paracrine growth factor signaling may be involved in the progression of normal colonic mucosa to adenoma, and modulated by dietary factors related to energy balance, oxidative stress, and inflammation.
- Subjects
DIET; TRANSFORMING growth factors-beta; TRANSFORMING growth factors; BIOMARKERS; COLON (Anatomy); ADENOMA
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA166
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.5.a166-c