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- Title
Association of the rs9939609 gene variant in FTO with insulin resistance, cardiovascular risk factor and serum adipokine levels in obese patients.
- Authors
de Luis, Daniel Antonio; Aller, Rocío; Izaola, Olatz; Primo, David; Romero, E.; De Luis, Daniel A
- Abstract
<bold>Introduction: </bold>The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels.<bold>Material and Methods: </bold>A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured.<bold>Results: </bold>Insulin (122.2 ± 101.8 pmol/L vs. 104.5 ± 61.5 pmol/L vs.112.1 ± 74.3 pmol/L:p < 0.05) and HOMA-IR values (4.76 ± 4.4 vs. 3.71 ± 2.5 vs.3.76 ± 3.1;p < 0.05) were higher in TT group than AT and AA groups. Triglycerides values were higher in TT group than AA group (1.42 ± 0.71 mmol/L vs.1.39 ± 0.69 mmol/L vs.1.23 ± 0.64 mmol/L;p < 0.05). Adiponectin levels were lower in TT genotype group than AA genotype group (35801.2 ± 35,912.3 ng/L vs.26,718.1 ± 36,323.1 ng/L vs. 21,112.3 ± 25,623.1 ng/L p < 0.05).<bold>Conclusion: </bold>The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obese patients with TT variant.
- Subjects
ADIPOKINES; CARDIOVASCULAR diseases risk factors; HUMAN genetic variation; INSULIN resistance; OBESITY; OVERWEIGHT persons; GENETICS; CARDIOVASCULAR diseases; PEPTIDE hormones; TRIGLYCERIDES; CROSS-sectional method
- Publication
Nutrición Hospitalaria, 2016, Vol 33, Issue 5, p1102
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.20960/nh.573