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- Title
Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes.
- Authors
GanLin He; ChunYan Wang; QingEn Li; Huo Tan; FuXiong Chen; ZhenQian Huang; BaoDan Yu; LiXia Zheng; RunHui Zheng; Dan Liu
- Abstract
Background There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood. Objective The objective of the present investigation was to explore the clinical and laboratory features of seven patients with AML-M2/M3. Method We retrospectively assessed cell morphology, cytochemistry, immunophenotype, cytogenetics, and clinical features of seven patients with this rare subtype of AML. Results All seven cases had thrombocytopenia, coagulation abnormalities, >20% myeloblasts and abnormal promyelocytes. The PML/RARa fusion gene was present in six patients and two patients presented a mixed PML/RARa and AML1/ETO genotype. Five cases achieved CR and two cases did not achieve remission and one case transform into AML-M2 after CR1. Conclusions The clinical and laboratory features of seven patients with AML-M2/M3 are demonstrated in the present study, providing information on the FAB sub-classification.
- Subjects
ACUTE myeloid leukemia; CELL morphology; CYTOCHEMISTRY; BONE marrow; MYELOPEROXIDASE; FLOW cytometry
- Publication
Cancer Cell International, 2014, Vol 14, Issue 1, p1
- ISSN
1475-2867
- Publication type
Article
- DOI
10.1186/s12935-014-0111-y