We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An evaluation of ascitic calprotectin for diagnosis of ascitic fluid infection in children with cirrhosis.
- Authors
Honar, Naser; Nezamabadipour, Najmeh; Dehghani, Seyed Mohsen; Haghighat, Mahmood; Imanieh, Mohammad Hadi; Ataollahi, Maryam; Shakibazad, Nader; Javaherizadeh, Hazhir
- Abstract
<bold>Background: </bold>The most common infection in children with the hepatic disease with or without cirrhotic ascites is spontaneous bacterial peritonitis (SBP), which occurs in the absence of an evident intra-abdominal source of infection. The present study aims to assess the value of calprotectin in ascitic fluid in the diagnosis of ascitic fluid infection in children with liver cirrhosis.<bold>Materials and Methods: </bold>In this cross-section study, 80 children with underlying liver disease who attended the Hepatology and Emergency Department in Shiraz University Hospitals were studied. All the patients were evaluated by a thorough history, clinical examination, laboratory investigations, diagnostic paracentesis with PMNLs count, and Calprotectin, which was measured in 1 mL ascitic fluid by ELISA.<bold>Results: </bold>Thirty-five patients (43.75%) were diagnosed with ascitic fluid infection. Of these children 6 cases had positive ascitic fluid culture (SBP). Calprotectin was high in AFI patients with a statistically significant difference in AFI patients compared to non-AFI patients. The cut-off levels were 91.55 mg /L and the area under the curve was 0.971. So it can serve as a sensitive and specific diagnostic test for detection of AFI in children with underlying liver disease.<bold>Conclusion: </bold>Elevated ascitic calprotectin levels in cirrhotic patients are a diagnostic and reliable marker for the detection of AFI and are considered a surrogate marker for PMN.
- Subjects
ASCITIC fluids; CALPROTECTIN; JUVENILE diseases; INTRA-abdominal infections; CIRRHOSIS of the liver
- Publication
BMC Pediatrics, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2431
- Publication type
journal article
- DOI
10.1186/s12887-022-03433-9