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- Title
Protecting group-free synthesis of the fungicide Mandipropamid.
- Authors
Annapurna, K.; Subba Reddy, B. V.; Narsaiah, A. Venkat
- Abstract
A simple and efficient protecting group free synthesis of a relatively new fungicide Mandipropamid has been achieved in five steps, with an excellent overall yield. The synthesis started from commercially available starting materials like vanillin and p-chloroacetophenone. The key steps involved in the synthesis are the Henry and Cannizzaro reactions, as well as amide formation through a carboxylic acid-amine coupling step.
- Subjects
CARBOXYLIC acids; NITROALDOL reactions; FREE groups; FUNGICIDES
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2023, Vol 2023, p1
- ISSN
1551-7004
- Publication type
Article
- DOI
10.24820/ark.5550190.p012.023