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- Title
Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARα)
- Authors
Bihan, Hélène; Rouault, Christine; Reach, Gérard; Poitout, Vincent; Staels, Bart; Guerre-Millo, Michèle
- Abstract
Abstract: This study tests the hypothesis that islet peroxisome proliferator-activated receptor alpha (PPARα) influences insulin secretion. Freshly isolated islets of normoglycemic PPARα-null mice display no major alteration of glucose-stimulated insulin release. However, after 24h of culture in high glucose, PPARα-null islets exhibit elevated basal insulin secretion and fail to increase insulin mRNA. 24-h culture with palmitate replicates this phenotype in wild-type islets. The data suggest that PPARα is needed to ensure appropriate insulin secretory response in situation of short-term hyperglycemia, likely by maintaining islet lipid homeostasis. As such, islet PPARα could contribute to delay the progression of type 2 diabetes.
- Subjects
HYPOGLYCEMIC agents; PANCREATIC secretions; BIOLOGICAL transport; ISLANDS of Langerhans
- Publication
FEBS Letters, 2005, Vol 579, Issue 11, p2284
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.03.020