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- Title
Modulation of Ca<sub>v</sub>3.2 T-type Ca<sup>2+</sup> channels by protein kinase C
- Authors
Park, Jin-Yong; Jeong, Seong-Woo; Perez-Reyes, Edward; Lee, Jung-Ha
- Abstract
Although T-type Ca2+ channels have been implicated in numerous physiological functions, their regulations by protein kinases have been obscured by conflicting reports. We investigated the effects of protein kinase C (PKC) on Cav3.2 T-type channels reconstituted in Xenopus oocytes. Phorbol-12-myristate-13-acetate (PMA) strongly enhanced the amplitude of Cav3.2 channel currents (∼3-fold). The augmentation effects were not mimicked by 4α-PMA, an inactive stereoisomer of PMA, and abolished by preincubation with PKC inhibitors. Our findings suggest that PMA upregulates Cav3.2 channel activity via activation of oocyte PKC.
- Subjects
CALCIUM channels; PROTEIN kinases; XENOPUS
- Publication
FEBS Letters, 2003, Vol 547, Issue 1-3, p37
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00665-3