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- Title
A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent <sup>18</sup>F-FECNT and its in vivo evaluations.
- Authors
Liang, Sheng; Chen, Zhengping; Ma, Yufei; Guo, Jun; Wang, Hui
- Abstract
2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-[ 18F]fluoroethyl)nortropane ([ 18F]-FECNT) is a potential dopamine transporter PET imaging agent. However, its current radio-synthesis is tedious and time consuming. In this article, we reported a fully automatic method for the synthesis of [ 18F] FECNT through only one step, using a TRACERlab FX N module, with decay corrected radiochemical yield of 25 ± 5 % ( n = 5). The total synthesis time was 50–55 min. The synthesized [ 18F]FECNT was evaluated in vivo in Parkinson’s disease model rats.
- Subjects
DOPAMINE; POSITRON emission tomography; RADIOCHEMICAL yield; ORGANIC synthesis; FLUORINE isotopes; PARKINSON'S disease; MEDICAL imaging systems
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2013, Vol 298, Issue 3, p1969
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-013-2672-y