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- Title
Evaluation of the radiochemical impurities arising during the competitive fluorination of nosyl group during the synthesis of 3′-deoxy-3′-fluorothymidine, [<sup>18</sup>F]FLT.
- Authors
Nandy, S. K.; Krishnamurthy, N. V.; Rajan, M. G. R.
- Abstract
The study is aimed at the analysis and identification of radiochemical and chemical impurities present in [18F]FLT synthesized by a simplified combination-column purification procedure, instead of the currently used HPLC purification. HPLC analysis of the final product showed an anionic radioactive byproduct, which was established as [18F]4-FBSA. The identity of the product was also confirmed by the radiofluorination of nosyl chloride. Mass spectrum analysis of both a decayed sample of [18F]FLT and fluorinated nosyl chloride showed a major peak at 242. We have also investigated the possible interference of this byproduct during PET-imaging in rabbits.
- Subjects
FLUORINATION; RADIOCHEMISTRY; RADIOACTIVE waste purification; POLYETHYLENE terephthalate; RABBITS
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2010, Vol 283, Issue 1, p245
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-009-0322-1