We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery.
- Authors
Li, Haidong; Kim, Dayeh; Yao, Qichao; Ge, Haoying; Chung, Jeewon; Fan, Jiangli; Wang, Jingyun; Peng, Xiaojun; Yoon, Juyoung
- Abstract
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme‐reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image‐guided intraoperative surgeries with high signal‐to‐noise ratios. In this review, we mainly summarize the latest advancements in enzyme‐reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.
- Subjects
COMPUTER-assisted surgery; FLUORESCENT probes; TUMOR surgery; TUMOR diagnosis; DIAGNOSIS; MOLECULAR probes; MOLECULAR biology
- Publication
Angewandte Chemie, 2021, Vol 133, Issue 32, p17408
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202009796