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- Title
Role of Wnt3a in the pathogenesis of cancer, current status and prospective.
- Authors
Pashirzad, Mehran; Fiuji, Hamid; Khazei, Majid; Moradi-Binabaj, Maryam; Ryzhikov, Mikhail; Shabani, Mohammad; Avan, Amir; Hassanian, Seyed Mahdi
- Abstract
The Wnt signaling pathway plays a critical role in initiation, progression, invasion and metastasis of cancer. Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology and pathology of a number of diseases including cancer. Depending on cancer type, Wnt3a enhances or suppresses metastasis, cell proliferation and apoptosis of cancer cells. This review summarizes the role of Wnt3a in the pathogenesis of different cancers including colorectal, prostate, hepatocellular, lung and leukemia, for promoting greater understanding and clinical management of these diseases.
- Subjects
CARCINOGENESIS; CANCER cell proliferation; WNT signal transduction; PATHOLOGY; METASTASIS
- Publication
Molecular Biology Reports, 2019, Vol 46, Issue 5, p5609
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-019-04895-4