We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease.
- Authors
Saedi, Massoud; Vaisi-Raygani, Asad; Khaghani, Shahnaz; Shariftabrizi, Ahmad; Rezaie, M.; Pasalar, Parvin; Rahimi, Zohreh; Pourmotabbed, Tayebeh
- Abstract
The Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T may be considered an important genetic determinant of early-onset coronary artery disease (ECAD). In this study, association between MMP-9 1562C>T allele with plasma MMP-9 activity, homocysteine and lipid-lipoproteins level and ECAD in Iranian subjects was investigated. This case-control study consisted of 53 ECAD patients (age < 55 years) and unrelated late-onsets CAD (age > 70 years) who angiographically had at least 50% stenosis. MMP-9 1562C>T polymorphism was detected by PCRRFLP, plasma MMP-9 activity, serum lipid and homocysteine levels were determined by gelatin gel zymography, enzyme assay and by HPLC, respectively. The presence of MMP-9 1562C>T allele was found to be associated with ECAD (OR = 3.2, P = 0.001). The ECAD patients with MMP-9 1562C>T allele had higher MMP-9 activity ( P = 0.001), LDL-C ( P = 0.045), TC ( P = 0.02) and homocysteine ( P = 0.01) levels than the LCAD subjects. MMP-9 1562C>T allele is a risk factor for ECAD. The carriers of this allele have high levels of MMP-9 activity, LDL-C, TC and homocysteine ( P = 0.01), thus, are more likely to develop myocardial infarction and CAD at young age (less than 55 years).
- Subjects
METALLOPROTEINS; CORONARY disease; GENETIC polymorphisms; LIPID analysis; HOMOCYSTEINE; IRANIANS
- Publication
Molecular Biology Reports, 2012, Vol 39, Issue 1, p555
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-011-0770-x