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- Title
Distinct roles for S100a8 in early embryo development and in the maternal deciduum.
- Authors
Baker, J.R.; Jeffery, R.; May, R.D.; Mathies, M.; Spencer-Dene, B.; Poulsom, R.; Hogg, N.
- Abstract
S100a8 is a cytosolic protein expressed in myeloid cells where it forms a stable heterodimer with another S100 protein family member, S100a9. The S100a9−/− mouse is viable and phenotypically normal, whereas the S100a8−/− condition is embryonic lethal. We present evidence that S100a8, without S100a9, has a previously unrecognized role in embryo development between fertilization and the 8-cell stage at embryonic day (E) 2.5. S100a8 also has a second role in the maternal deciduum, where expression is associated with the vasculature from the E8.5 stage to the formation of mature placenta. Uterine natural killer cells that have a role in vascular remodelling colocalise with the S100a8 vascular expression in the metrial triangle. In inflammatory responses in peripheral tissues, S100a8 is a potent chemoattractant and also an anti-oxidant. Both roles may be important in the developing placenta. Thus we highlight two new S100a9-independent roles for S100a8 in early embryo development. Developmental Dynamics 240:2194-2203, 2011. © 2011 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2011, Vol 240, Issue 9, p2194
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.22709