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- Title
Clinical guides for atypical hemolytic uremic syndrome in Japan.
- Authors
Kato, Hideki; Nangaku, Masaomi; Hataya, Hiroshi; Sawai, Toshihiro; Ashida, Akira; Fujimaru, Rika; Hidaka, Yoshihiko; Kaname, Shinya; Maruyama, Shoichi; Yasuda, Takashi; Yoshida, Yoko; Ito, Shuichi; Hattori, Motoshi; Miyakawa, Yoshitaka; Fujimura, Yoshihiro; Okada, Hirokazu; Kagami, Shoji
- Abstract
Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In 2013, we developed diagnostic criteria to enable early diagnosis and timely initiation of appropriate treatment for aHUS. Recent clinical and molecular findings have resulted in several proposed classifications and definitions of thrombotic microangiopathy and aHUS. Based on recent advances in this field and the emerging international consensus to exclude secondary TMAs from the definition of aHUS, we have redefined aHUS and proposed diagnostic algorithms, differential diagnosis, and therapeutic strategies for aHUS.
- Subjects
HEMOLYTIC-uremic syndrome; HEMOLYTIC anemia; THROMBOCYTOPENIA; THROMBOTIC thrombocytopenic purpura; HEMOLYTIC-uremic syndrome diagnosis
- Publication
Clinical & Experimental Nephrology, 2016, Vol 20, Issue 4, p536
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-016-1276-6