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- Title
Anti‐viral innate immunity: Is it where type 1 diabetes really begins?
- Authors
Bruzzaniti, Sara; Piemonte, Erica; Lepore, Maria Teresa; Galgani, Mario
- Abstract
Type 1 diabetes (T1D) is a common multifactorial autoimmune disease resulting from the destruction of insulin-producing -cells in the pancreas as a consequence of dysregulated immune responses.[1] In the past few years, there has been a flurry of discoveries and advancements in our understanding of the immunopathogenic mechanisms at the basis of T1D development and progression. Herein, conventional dendritic cells display a pivotal role in inducing T1D upon pathogen infections as these cells can capture and present -cell-derived proteins and/or viral antigens, initiating the diabetogenic T cell-specific immune response[7] (Figure 1). Anti-viral innate immunity: Is it where type 1 diabetes really begins?.
- Subjects
TYPE 1 diabetes; NATURAL immunity; AUTOIMMUNE diseases; T cell receptors; IMMUNOREGULATION; COXSACKIEVIRUS diseases; KILLER cells; PENTRAXINS
- Publication
Diabetes/Metabolism Research & Reviews, 2023, Vol 39, Issue 5, p1
- ISSN
1520-7552
- Publication type
Article
- DOI
10.1002/dmrr.3623