We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reflections on a Copenhagen–Minneapolis Axis in Bioorganic Chemistry.
- Authors
Barany, George; Hansen, Paul R.
- Abstract
The international peptide community rejoiced when one of its most distinguished members, Morten Meldal of Denmark, shared the 2022 Nobel Prize in Chemistry. In fact, the regiospecific solid-phase "copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides" (CuACC) reaction—that formed the specific basis for Meldal's recognition—was reported first at the 17th American Peptide Symposium held in San Diego in June 2001. The present perspective outlines intertwining conceptual and experimental threads pursued concurrently in Copenhagen and Minneapolis, sometimes by the same individuals, that provided context for Meldal's breakthrough discovery. Major topics covered include orthogonality in chemistry; the dithiasuccinoyl (Dts) protecting group for amino groups in α-amino acids, carbohydrates, and monomers for peptide nucleic acids (PNA); and poly(ethylene glycol) (PEG)-based solid supports such as PEG–PS, PEGA, and CLEAR [and variations inspired by them] for solid-phase peptide synthesis (SPPS), solid-phase organic synthesis (SPOS), and combinatorial chemistry that can support biological assays in aqueous media.
- Subjects
COPENHAGEN (Denmark); MINNEAPOLIS (Minn.); SAN Diego (Calif.); BIOORGANIC chemistry; RING formation (Chemistry); PEPTIDE nucleic acids; SOLID-phase synthesis; COMBINATORIAL chemistry; NOBEL Prize in Chemistry
- Publication
Molecules, 2024, Vol 29, Issue 6, p1317
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29061317