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- Title
New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus.
- Authors
Anwar, Alaa; Elnaggar, Mohamed S.; Elissawy, Ahmed M.; Ibrahim, Nehal; Mándi, Attila; Kurtán, Tibor; Liu, Zhen; El-Ahmady, Sherweit H.; Kalscheuer, Rainer
- Abstract
In this study, we report the isolation of two new meroterpenoids, miniolutelide D (1) and miniolutelide E (13-epi-miniolutelide C) (2), along with two meroterpenoidal analogues (3 and 4) and two phenolic compounds (5 and 6) from the endophytic fungus Talaromyces purpureogenus derived from Punica granatum fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of 1 and 2 were determined using TDDFT-ECD calculations. Antimicrobial activity was evaluated. Compound 5 displayed significant activity against methicillin-resistant Staphylococcus aureus strain ATCC 700699 and moderate activity against S. aureus strain ATCC 29213.
- Subjects
ENDOPHYTIC fungi; TALAROMYCES; METHICILLIN-resistant staphylococcus aureus; PHENOLS; POMEGRANATE; SCHISANDRA; ANTI-infective agents
- Publication
Molecules, 2023, Vol 28, Issue 22, p7650
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28227650