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- Title
Synthetic Access to Aromatic α-Haloketones.
- Authors
Porré, Marre; Pisanò, Gianmarco; Nahra, Fady; Cazin, Catherine S. J.
- Abstract
α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.
- Subjects
ORGANIC synthesis; SUSTAINABILITY; HALOKETONES
- Publication
Molecules, 2022, Vol 27, Issue 11, p3583
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27113583