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- Title
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis.
- Authors
Ozgonul, Cem; Besirli, Cagri Giray
- Abstract
Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised patients, may create diagnostic challenges and lead to misdiagnosis and inappropriate treatment. Molecular biology techniques to diagnose ocular toxoplasmosis have been available for many years and are now accessible as standard laboratory tests in many countries. Aqueous humor or vitreous evaluation to detect parasite DNA by polymerase chain reaction or specific antibody may provide definitive evidence for rapid diagnosis. Oral pyrimethamine and sulfadiazine plus systemic corticosteroids are an effective therapy for ocular toxoplasmosis. Recent data supports the use of other treatment approaches, including intravitreal antibiotics. The aim of the present review is to discuss briefly the new diagnostic tools and treatment options for ocular toxoplasmosis.
- Subjects
TOXOPLASMOSIS diagnosis; TOXOPLASMOSIS treatment; TOXOPLASMA gondii; ETIOLOGY of diseases; MOLECULAR biology
- Publication
Ophthalmic Research, 2016, Vol 57, Issue 1, p1
- ISSN
0030-3747
- Publication type
Article
- DOI
10.1159/000449169